Instituto Médico Especializado Alexander Fleming - CABA, Buenos Aires
Instituto Médico Especializado Alexander Fleming - CABA, Buenos Aires
Av. Crámer 1180, CABA, Buenos Aires
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Our team
Medical staff
Gonzalo Giornelli
Federico Esteso
Yanina Pfluger
Juan O´Connor
Paola Andrea Ochoa
María Cecilia Foncuberta
Rodrigo Manso
María Calcagno
Jorge Carlos Nadal
Juan Pablo Sade
Adrian Nervo
Alejandra Tofalo
Claudio Marcelo Martin
Martín Ángel
Federico Losco
María Cecilia Paramos
Maria del Rosario Custidiano
Florencia Tsou
Brenda Oliva
Diego Enrico
Open studies
Lung cancer
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4) - KRYSTAL-4 - Mirati Therapeutics Inc.See more
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1% - RELATIVITY1093 - Bristol-Myers SquibbSee more
A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002) - MK-6070-002 - Merck Sharp & Dohme LLCSee more
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007) - KANDLELIT-007 - Merck Sharp & Dohme LLCSee more
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023] - MK-2870-023 - Merck Sharp & Dohme LLCSee more
Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007) - MK 2870-007 - Merck Sharp & Dohme LLCSee more
A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002) - INTerpath-002 - Merck Sharp & Dohme LLCSee more
A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013) - INTerpath-13 - Merck Sharp & Dohme LLCSee more
MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC (MK-1084-013) - KANDLELIT-013 - Merck Sharp & Dohme LLCSee more
A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion - MountainTAP-29 - Bristol-Myers SquibbSee more
A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015) - KANDLELIT-015 - Merck Sharp & Dohme LLCSee more
A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201) - ROSETTA Lung-201 - Bristol-Myers SquibbSee more
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7 - KRYSTAL-7 - Mirati Therapeutics Inc.See more
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01) - IZABRIGHT-Lung01 - Bristol-Myers SquibbSee more
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009) - INTerpath-009 - Merck Sharp & Dohme LLCSee more
Breast Cancer
A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015) - OMAHA-015 - Merck Sharp & Dohme LLCSee more
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01) - IZABRIGHT-Breast01 - Bristol-Myers SquibbSee more
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010) - MK 2870-010 - Merck Sharp & Dohme LLCSee more
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012) - MK-2870-012 - Merck Sharp & Dohme LLCSee more
A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011) - TroFuse-011 - Merck Sharp & Dohme LLCSee more
A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer - Hoffmann-La RocheSee more
RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive - BREnnA - Hoffmann-La RocheSee more
Non-Hodgkin Lymphoma
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010). - BELLWAVE-010 - Merck Sharp & Dohme LLCSee more
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003) - waveLINE-003 - Merck Sharp & Dohme LLCSee more
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) - BRUIN-CLL-314 - Loxo Oncology, Inc.See more
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) - BRUIN-CLL-314 - Loxo Oncology, Inc.See more
A Clinical Trial of MK-1045 and Rituximab in People With Follicular Lymphoma (MK-1045-007) - MK-1045-007 - Merck Sharp & Dohme LLCSee more
A Clinical Study of MK-1045 in People With Non-Hodgkin Lymphoma (MK-1045-008) - MK-1045-008 - Merck Sharp & Dohme LLCSee more
A Clinical Study of MK-1045 in People With Non-Hodgkin Lymphoma (MK-1045-008) - MK-1045-008 - Merck Sharp & Dohme LLCSee more
Colorectal cancer
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer - MOUNTAINEER-03 - Seagen Inc.See more
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer - MOUNTAINEER-03 - Seagen Inc.See more
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer - MOUNTAINEER-03 - Seagen Inc.See more
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012) - MK-1084-012/KANDLELIT-012 - Merck Sharp & Dohme LLCSee more
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012) - MK-1084-012/KANDLELIT-012 - Merck Sharp & Dohme LLCSee more
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer - ROSETTA CRC-203 - Bristol-Myers SquibbSee more
Prostate cancer
A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02) - MK-2400-01A/IDeate-Prostate02 - Merck Sharp & Dohme LLCSee more
An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC. - PSMA-DC - Novartis PharmaceuticalsSee more
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003) - OMAHA-003 - Merck Sharp & Dohme LLCSee more
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003) - OMAHA-003 - Merck Sharp & Dohme LLCSee more
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001) - IDeate-Prostate01 - Merck Sharp & Dohme LLCSee more
Gastroesophageal cancer
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204) - ROSETTA GI 204 - Bristol-Myers SquibbSee more
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204) - ROSETTA GI 204 - Bristol-Myers SquibbSee more
Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer - Destiny-Gastric05 - Daiichi SankyoSee more
Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer - Destiny-Gastric05 - Daiichi SankyoSee more
Endometrial Cancer
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01) - Bluestar-Endometrial01 - AstraZenecaSee more
A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015) - OMAHA-015 - Merck Sharp & Dohme LLCSee more
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29) - TroFuse-033 - Merck Sharp & Dohme LLCSee more
Multiple myeloma
A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM) - DREAMM-10 - GlaxoSmithKlineSee more
A Study Evaluating the Prophylactic Use of Tocilizumab to Prevent Cytokine Release Syndrome With Ramantamig Administration in Participants With Relapsed/Refractory Multiple Myeloma - TRI Pro - Janssen Research & Development, LLCSee more
MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide) - MagnetisMM-32 - PfizerSee more
Bladder Cancer
A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011) - INTerpath-011 - Merck Sharp & Dohme LLCSee more
A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031) - TroFuse-031 - Merck Sharp & Dohme LLCSee more
A Study to Evaluate TAR-210 Versus Intravesical Chemotherapy Treatment in Participants With High Risk Non-Muscle-Invasive Bladder Cancer - MoonRISe-3 - Janssen Research & Development, LLCSee more
Ovarian cancer
A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015) - OMAHA-015 - Merck Sharp & Dohme LLCSee more
A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103) - TroFuse-022 - Merck Sharp & Dohme LLCSee more
Kidney cancer
A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033) - LITESPARK-033 - Merck Sharp & Dohme LLCSee more
A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034) - LITESPARK-034 - Merck Sharp & Dohme LLCSee more
Leukemia
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010). - BELLWAVE-010 - Merck Sharp & Dohme LLCSee more
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) - BRUIN-CLL-314 - Loxo Oncology, Inc.See more
Gastric cancer
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204) - ROSETTA GI 204 - Bristol-Myers SquibbSee more
Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer - Destiny-Gastric05 - Daiichi SankyoSee more
Carcinoid Syndrome
Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen - CAREFNDR - Crinetics Pharmaceuticals Inc.See more
Pancreatic cancer
Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen - CAREFNDR - Crinetics Pharmaceuticals Inc.See more
Liver cancer
Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen - CAREFNDR - Crinetics Pharmaceuticals Inc.See more
Gastrointestinal Cancer
Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen - CAREFNDR - Crinetics Pharmaceuticals Inc.See more
Solid tumors
A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015) - OMAHA-015 - Merck Sharp & Dohme LLCSee more
Skin cancer
IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301) - PRISM-MEL-301 - Immunocore LtdSee more
Myeloproliferative syndromes
KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment - BOREAS - Kartos Therapeutics, Inc.See more
Lymphoma
A Clinical Study of MK-1045 in People With Non-Hodgkin Lymphoma (MK-1045-008) - MK-1045-008 - Merck Sharp & Dohme LLCSee more
