Last updated 40 hours ago
A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006)
60 patients around the world
Available in Colombia
Merck Sharp & Dohme LLC
2Research sites
60Patients around the world
This study is for people with
Leukemia
Chronic lymphocytic leukemia
Non-Hodgkin Lymphoma
Small lymphocytic lymphoma
Requirements for the patient
From 18 Years
All Gender
Medical requirements
- Has histologically confirmed chronic lymphocytic leukemia (CLL)/small lymphocytic leukemia (SLL) active disease that is relapsed/refractory (r/r) to prior therapy.Has confirmed CD19-positive disease.If human immunodeficiency virus (HIV)-positive, has well-controlled HIV on antiretroviral therapy.If hepatitis B surface antigen (HBsAg)-positive, has undetectable hepatitis B virus (HBV) viral load.If has a history of hepatitis C virus (HCV) infection, has undetectable HCV viral load.
- Has a history of serious cardiovascular and cerebrovascular diseases.Has a history or presence of central nervous system disease.Is HIV-infected with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease.Has a diagnosis of immunodeficiency.Has a known additional malignancy that is progressing or required active treatment within the past 2 years.Has active autoimmune disease (not related to underlying leukemia diagnosis) that required systemic treatment in the past 2 years.Has any active acute graft versus host disease (GvHD) or active chronic GvHD requiring systemic treatment.Has active infection requiring systemic therapy.Has not adequately recovered from major surgery or has ongoing surgical complications.Has a diagnosis of Richter Transformation.
Sites
Hospital Pablo Tobón Uribe
Recruiting
Los Cobos Medical Center - Colombia
Recruiting
SponsorMerck Sharp & Dohme LLC
Study typeInterventional
Conditions
Chronic lymphocytic leukemiaSmall lymphocytic lymphoma
Requirements
From 18 YearsAll Gender
Unique study IDclinicaltrials.gov
NCT07709000
