Last updated 4 months ago
Safety and Potency of a High Cabergoline Dosage in Microprolactinomas
70 patients around the world
Available in Brazil
Prolactinoma is the most common subtype of pituitary adenoma, and dopamine agonists are the gold standard for treatment, primarily CAB. The SPARAGMOS trial will be an interventional, randomized, open-label, multicenter study utilizing a high dose of CAB for ~6 months to suppress prolactin levels, with the hypothetical goal of achieving greater tumor apoptosis and remission rates. The control group will receive CAB for two years at the lowest dose necessary to achieve normoprolactinemia, as per current guidelines. Of note, for both groups, the final cumulative dose will be similar. The findings from this trial have the potential to inform and redefine future therapeutic strategies for microprolactinoma.
University of Sao Paulo General Hospital
11Research sites
70Patients around the world
This study is for people with
Prolactinoma
Requirements for the patient
From 18 Years
Female
Medical requirements
- Willing and able to provide written informed consent prior to any study-related procedures.Adults >18 years old.Pre-menopausal women.Presence of signs and symptoms matching prolactinoma.Hyperprolactinemia, defined as a prolactin (PRL) level ≥2 times the local laboratory maximum level of normality, present at the time of enrolment.Presence of an identifiable pituitary mass on MRI with a maximum diameter of less than 1cm, independently of Knosp/invasiveness of the cavernous sinus.Treatment naïve.Females who engage in heterosexual intercourse must agree to use either a highly effective or a clinically acceptable method of contraception from the beginning of screening to the last study visit, which will include:Hysterectomy or bilateral salpingectomy.Bilateral tubal occlusion or ligation.Vasectomized partner.Intrauterine device (copper or hormonal).Progestogen-only contraception (oral, injectable or implantable).Male or female condom with or without spermicide.Sexual abstinence (only when it is the usual and preferred lifestyle of the subject).
- History of primary hyperparathyroidism.Use of combined hormonal contraceptive within the past 4 weeks.Pregnancy or current pregnancy desire.Prolactinoma associated with a known genetic syndrome.Familial history of pituitary adenoma.Renal failure (estimated glomerular filtration rate <30 mL/min /1.73m2).IGF-1 level above the age-adjusted normal range of the local laboratory (IGF 1 >1x ULNR).Idiopathic hyperprolactinemia (normal MRI) or presence of macroprolactinemia.Concomitant mental condition rendering her unable to understand the nature, scope, and possible consequences of the study, and/or decompensated psychiatric disease (i.e. gambling or severe obsessive-compulsive disorder), as judged by the Investigator.Chronic use of drugs related to hyperprolactinemia (such as metoclopramide, methyldopa, ranitidine, and opioid-related analgesics).Resistant prolactinoma, defined as non-normalization of PRL levels with 2mg/w of CAB.Patients in the high dosage group who did not use 3.5mg/w of CAB for an entire 6 months (due to intolerance or non-compliance) or failed to achieve the target dose for any other reason.Active malignant disease within the last 5 years, except basal and squamous cell carcinoma of the skin with complete local excision.Any decompensated chronic condition (i.e. heart failure NYHA 3-4, diabetes with HbA1c >8.5%, hypothyroidism with TSH >10 mIU/L) that, in the opinion of the Investigator, would impede compliance, hinder completion of the study, compromise the well-being of the patient, or interfere with the study outcomes.Male sex.Cushing stigmas (moon face, muscle weakness, red striation) or suspicious.Prior radiotherapy of the pituitary gland area for any reason.Additional pituitary tumor-directed therapy, including temozolomide, everolimus, lapatinib, or cytotoxic chemotherapy.Hepatopathy with AST/TGO or ALT/TGP >3x the upper limit of normality.
Sites
Hospital Das Clínicas Da Universidade Federal de Minas Gerais - UFMG
Recruiting
Faculdade de Medicina da Universidade Estadual Paulista - Campus de Botucatu - UNESP
Recruiting
Hospital de Clínicas - Universidade Estadual de Campinas - UNICAMP
Recruiting
Hospital das Clínicas da Universidade Federal de Goiás - UFG
Recruiting
Hospital Moinhos de Vento - Porto Alegre
Recruiting
Irmandade da Santa Casa de Misericórdia de Porto Alegre
Recruiting
Hospital das Clínicas Universidade Federal de Pernambuco - UFPE
Recruiting
Universidade Federal do Rio de Janeiro - Faculdade de Medicina - UFRJ
Recruiting
Hospital das Clínicas da FMUSP - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP
Recruiting
Santa Casa de São Paulo (IPITEC) - Santa Casa Instituto de Pesquisa
Recruiting
StudySPARAGMOS
SponsorUniversity of Sao Paulo General Hospital
Study typeInterventional
Conditions
Prolactinoma
Requirements
From 18 YearsFemale
Unique study IDclinicaltrials.gov
NCT07463235
