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Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

900 patients around the world

Available in Puerto Rico, Argentina, United States, Mexico, Brazil

Eli Lilly and Company

30Research sites

900Patients around the world

This study is for people with

Osteoarthritis

Obesity

From 18 Years

All Gender

: Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening.
Have a stable body weight (less than 5% body weight change) for 90 days prior to screening.
Have tried at least once to lose weight through diet but were unsuccessful.
Have osteoarthritis of the knee and at least one of the following conditions.
Be over 50 years old.
Have morning knee stiffness that lasts about 30 minutes.
Have a crackling or grinding sound or feeling in the knee.

: Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before screening).
Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening).
Have type 1 diabetes, type 2 diabetes, or any other type of diabetes.
Have an active knee infection.
Have had within 90 days prior to screening.
Heart attack.
Stroke.
Coronary artery revascularization.
Unstable angina.
Hospitalization due to congestive heart failure.
Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure.
Have taken medications or alternative remedies intended for weight loss within 90 days of screening.

Organización Médica de Investigación (OMI)

Uruguay 725 PB , Buenos Aires, CP: 1015

STAT Research - CABA

Av. Callao 875, CABA, Buenos Aires

CIPREC Centro de Investigación y Prevención Cardiovascular - CABA

Av. Pueyrredón 1746 2° A, C1119 Cdad. Autónoma de Buenos Aires, Argentina

Centro Médico Arsema

Av. Álvarez Thomas 1131 piso 9 dto c, C1427CCL Cdad. Autónoma de Buenos Aires, Argentina

Centro de Investigaciones Clínicas Baigorria

L. Paganini 324, S2152 Granadero Baigorria, Santa Fe, Argentina

Instituto de Especialidades de la Salud Rosario Clínica del Tórax

España 931, Rosario, Santa Fe

Instituto Médico de Alta Complejidad San Isidro IMACSI

Av. del Libertador 16958, San Isidro, Buenos Aires

Centro Polivalente de Asistencia e Investigación Clínica - CER San Juan

Laprida 532 Este, San Juan

Centro de Investigaciones Médicas Tucumán

Lavalle 506, T4000 San Miguel de Tucumán, Tucumán, Argentina

Aprillus Asistencia e Investigación

Terrada 89, Flores, CABA

StudyENLIGHTEN-4

SponsorEli Lilly and Company

Study typeInterventional

Conditions

OsteoarthritisObesity

Requirements

From 18 YearsAll Gender

Unique study IDclinicaltrials.gov

NCT07353931