Last updated 2 months ago

Epicardial Cardiac Fat-CT (EPIC-CT)

136 patients around the world

Available in Mexico

This randomized, open-label clinical trial will assess the effects of dapagliflozin compared to semaglutide on epicardial fat in patients with ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction over a 12-month period. Epicardial fat will be measured by simple coronary tomography during initial hospitalization for infarction and after 12 months of treatment with both medications. It will include patients over 18 years old with STEMI and NSTEMI, with or without a diagnosis of type 2 diabetes and clinical obesity. Patients will be discharged following treatment guidelines, and their adherence to medication and tolerability will be monitored.

Instituto Mexicano del Seguro Social

1Research sites

136Patients around the world

This study is for people with

Coronary heart disease

Acute myocardial infarction

Requirements for the patient

From 18 Years

All Gender

Medical requirements

: Criteria for the fourth definition of acute myocardial infarction with and without ST-segment elevation.
Diagnosed with type 2 diabetes.
Initial serum high-sensitivity CRP value > 2.0 mg/L.
Clinically obese.
LVEF >50%.

: Patients who have recently received immunosuppressive therapy.
Patients with a history of ischemic heart disease.
Known allergy to any of the medications used.
Use of any of the study drugs more than 6 months prior to randomization.
Patients experiencing diabetic ketoacidosis.
Patients with hemodynamic instability (mean arterial pressure <60 mmHg while on vasopressors).
Pregnant women.
Patients with a history or current diagnosis of cancer.
Patients with documented active infections, such as pneumonia or urinary tract infections.
Patients with pancreatitis.

Sites

Hospital Regional de Alta Especialidad del Bajío

Recruiting

Blvd. Milenio, Fracciones de los Aguirre, 37544 León de los Aldama, Gto., Mexico

StudyEPIC-CT

SponsorInstituto Mexicano del Seguro Social

Study typeInterventional

Conditions

Acute myocardial infarction

Requirements

From 18 YearsAll Gender

Unique study IDclinicaltrials.gov

NCT07297589