Last updated 48 days ago
Obstructive Sleep Apnea Treatment From Acute to Chronic Phase of Stroke
425 patients around the world
Available in Brazil
Obstructive sleep apnea (OSA) is present in more than 70% of acute stroke patients, and
has been related to poor short-and long-term outcomes. The treatment of choice for OSA is
continuous positive airway pressure (CPAP).
The objective of this prospective, multicenter, randomized study is to evaluate the
impact of CPAP treatment on clinical outcomes in post-stroke patients. Respiratory
polygraphy will be performed in all eligible participants, and those with severe OSA will
be randomized to receive either CPAP therapy or conservative management. CPAP use will
initiated within the first 48-72 hours of hospital admission and continued through 2
years follow-up.
Hospital das Clínicas de Ribeirão Preto
1Research sites
425Patients around the world
This study is for people with
Sleep disorders
Sleep apnea
Stroke
Ischemic stroke
Requirements for the patient
To 80 Years
All Gender
Medical requirements
- Supratentorial non-lacunar ischemic stroke, including anterior, middle, and posterior cerebral artery territories.Aged 18 to 80 years.Symptom onset or symptom recognition to admission < 12 hours.NIHSS score ≥ 4 and ≤ 20 at enrollment.Signed informed consent form obtained from the participant or their legal representative.
- Prior stroke.Previous diagnosis of OSA with current CPAP use or previously failed CPAP.Pre-stroke disability (mRS > 1).Coma or stupor.Orotracheal intubation.Clinical instability or severe pre-existing illness (e.g., heart failure, oxygen-dependent COPD, renal or hepatic failure).Psychomotor agitation.High likelihood of neurosurgical intervention within the first 48 hours.Oxygen therapy >2 L/min.Known severe neurological disease (e.g., dementia, Parkinson's disease, multiple sclerosis, or other neurodegenerative conditions).Chronic alcohol or drug use with high risk of withdrawal during hospitalization.Pregnant or suspected pregnant women.Inability to complete follow-up for any reason.Any contraindication to CPAP use.
Sites
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Recruiting
StudyATACS
SponsorHospital das Clínicas de Ribeirão Preto
Study typeInterventional
Conditions
Sleep apneaIschemic stroke
Requirements
To 80 YearsAll Gender
Unique study IDclinicaltrials.gov
NCT07044830
