Last updated 11 days ago

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

620 patients around the world
Available in Puerto Rico, United States, Brazil
All participants in this study will take either the study medicine (PF-07328948) tablets, or placebo tablets, once daily, by mouth, every day for 36 weeks. The study determines if the study medicine (PF-07328948) is safe and effective compared to placebo in people with heart failure who are already taking standard-of-care medications for heart failure that include sodium-glucose cotransporter 2 (SGLT2) inhibitors. Participants will be involved in this study for about 48 weeks. During this time, participants will visit the study clinic 15 times. In general, 5 of these visits may be performed at home by phone and the other 10 visits will take place at the study site.
Pfizer
5Research sites
620Patients around the world

This study is for people with

Heart failure

Requirements for the patient

To 79 Years
All Gender

Medical requirements

Aged 18 years to < 80 years.
Clinically confirmed to have a diagnosis of heart failure for at least 3 months.
New York Heart Association Class II-IV symptoms.
Left ventricular ejection fraction greater than 40%.
Kansas City Cardiomyopathy Questionnaire-23 Total Symptom Score < 85.
Six-minute walking distance greater than 75 meters.
Type 1 diabetes mellitus, liver cirrhosis or any condition that can possibly affect how the medicine is absorbed into the body.
Major surgery scheduled for the duration of the study, affecting walking ability in the opinion of the study doctor.
History of heart transplantation, or currently listed for a heart transplant, or current planned use of IV vasodilators and/or inotropes.
Prior intolerance/known hypersensitivity to an SGLT2 inhibitor or contraindication to an SGLT2 inhibitor.

Sites

Centro Paulista de Investigação Clínica - CEPIC
R. Moreira e Costa, 342 - Ipiranga, São Paulo - SP, 04266-010
Cardresearch - Cardiologia Assistencial e de Pesquisa LTDA
R. Domingos Vieira, 300 - Sala 606 - Santa Efigênia, Belo Horizonte - MG, 30150-242, Brazil
Núcleo de Pesquisa Clínica do Rio Grande do Sul - NPCRS
Rua Mostardeiro 5/310, Porto Alegre, Rio Grande do Sul
Instituto De Pesquisa Clinica de Campinas - Ipecc
Rua Oswaldo Oscar Barthelson, 1209 - Jardim Pauliceia, Campinas - SP, 13060-080
Research and Cardiovascular Corp
X9WJ+WGG, Ponce, 00717, Puerto Rico
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