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A Study to Assess Efficacy and Safety of JNJ-77242113 Compared to Placebo and Ustekinumab in Participants With Moderate to Severe Plaque Psoriasis

675 patients around the world

Available in Argentina, United States

Janssen Research & Development, LLC

7Research sites

675Patients around the world

This study is for people with

Psoriasis

Plaque psoriasis

From 12 Years

All Gender

: Diagnosis of plaque psoriasis, with or without psoriatic arthritis (PsA), prior to the first administration of study intervention.
Total body surface area (BSA) greater than or equal to 10 percent (%) at screening and baseline.
Total psoriasis area and severity index (PASI) greater than or equal to 12 at screening and baseline.
Total investigator global assessment (IGA) greater than or equal to 3 at screening and baseline.
Candidate for phototherapy or systemic treatment for plaque psoriasis.

: Nonplaque form of psoriasis, for example, erythrodermic, guttate, or pustular.
Current drug-induced psoriasis, for example, a new onset of psoriasis or an exacerbation of psoriasis from beta blockers, calcium channel blockers, or lithium.
Known allergies, hypersensitivity, or intolerance to JNJ-77242113, ustekinumab, or its excipients.
Major surgical procedure within 8 weeks before screening, or will not have fully recovered from surgical procedure, or has a surgical procedure planned during the time the participant is expected to participate in the study.
Transplanted organ, with exception of a corneal transplant greater than 12 weeks before the first administration of study intervention.

CIPREC Centro de Investigación y Prevención Cardiovascular - CABA

Recruiting

Av. Pueyrredón 1746 2° A, C1119 Cdad. Autónoma de Buenos Aires, Argentina

Instituto de Especialidades de la Salud Rosario Clínica del Tórax

Recruiting

España 931, Rosario, Santa Fe

Centro de Investigaciones Médicas Tucumán

Recruiting

Lavalle 506, T4000 San Miguel de Tucumán, Tucumán, Argentina

Mautalen - Salud e Investigación - CABA

Recruiting

Azcuénaga 1860 piso 8, C1128AAF Cdad. Autónoma de Buenos Aires, Argentina

Halitus Instituto Médico - CABA, Buenos Aires

Recruiting

Marcelo T. de Alvear 2084, CABA, Buenos Aires

Investigaciones Médicas IMOBA SRL

Recruiting

Viamonte 2168, C1056ABH Cdad. Autónoma de Buenos Aires, Argentina

Centro Privado de Medicina Familiar Mindout Research

Recruiting

Jose Pedro Varela 3901, CABA, Buenos Aires

StudyICONIC-ASCEND

SponsorJanssen Research & Development, LLC

Study typeInterventional

Conditions

Plaque psoriasis

Requirements

From 12 YearsAll Gender

Unique study IDclinicaltrials.gov

NCT06934226