Last updated 29 days ago
Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
1220 patients around the world
Available in Brazil, United States
The purpose of this study is to assess the efficacy and tolerability of rilvegostomig in
combination with bevacizumab with or without tremelimumab as first-line treatment in
participants with advanced HCC. The study comprises 2 parts - a safety lead-in and a
randomised period. Prior to the start of the randomised period of the study, a single-arm
safety lead-in period will be applied to evaluate the safety and tolerability of
rilvegostomig in combination with bevacizumab and tremelimumab.
AstraZeneca
1220Patients around the world
This study is for people with
Liver Cancer
Hepatocellular Carcinoma
Requirements for the patient
From 18 Years
All Gender
Medical requirements
- Locally advanced or metastatic and/or unresectable HCC.WHO/ECOG performance status of 0 or 1.BCLC stage B (that is not eligible for locoregional therapy) or stage C. Child-Pugh Score class A.At least one measurable target lesion.Adequate organ and bone marrow function measured during the screening period.Disease that is not amenable to curative surgical and/or locoregional therapies. For participants who received locoregional therapy for HCC, locoregional therapy must have been completed ≥ 28 days prior to the baseline scan for the current study.
- Any evidence of uncontrolled intercurrent diseases.Active or prior documented autoimmune or inflammatory disorders requiring chronic treatment with steroids or other immunosuppressive treatment.History of another primary malignancy.Persistent toxicities caused by previous anti-cancer therapy excluding alopecia, not yet improved to Grade ≤ 1 or baseline.Clinically meaningful ascites, pleural effusion, or pericardial effusion requiring non-pharmacologic intervention to maintain symptomatic control within 6 months prior to the first scheduled dose.History of active primary immunodeficiency or active infection.History of hepatic encephalopathy.Current or recent (within 10 days of first dose of study treatment) use of aspirin (≥ 325 mg/day) or treatment with dipyridamole, ticlopidine, clopidogrel, and cilostazol.Current or recent (within 10 days prior to study treatment start) use of full-dose oral or parenteral anticoagulants or thrombolytic agents for therapeutic (as opposed to prophylactic) purposes is ineligible.Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC.Central nervous system metastases or spinal cord compression (including asymptomatic and adequately treated disease).Prior treatment with anti-CTLA-4 and/or anti-TIGIT.Radiotherapy within 28 days and abdominal/pelvic radiotherapy within 60 days prior to initiation of study treatment, except palliative radiotherapy to bone lesions within 7 days prior to initiation of study treatment.
StudyARTEMIDE-HCC01
SponsorAstraZeneca
Study typeInterventional
Conditions
Hepatocellular Carcinoma
Requirements
From 18 YearsAll Gender
Unique study IDclinicaltrials.gov
NCT06921785
