Last updated 30 days ago

Efficacy of Short-course Blinatumomab for MRD Erradication in B-ALL

30 patients around the world
Available in Mexico
During the proposed treatment, blinatumomab therapy will be assigned as follows: Blinatumomab 17.5 mcg per day for 2 days, followed by blinatumomab 28 mcg per day for 5 days. Dexamethasone 20 mg will be applied one hour before starting dose. The immunotherapy will be applied as a 24-hour continuous infusion. The scheduled appointments will be on the initial day of blinatumomab, when the patient will be discharged from hospital and evaluation will be performed on day 10 with bone marrow aspiration and MRD assessment trough next generation flow cytometry. The results will be given at the appointment on day 14, along with an assessment profile for HSCT.
Hospital Universitario Dr. Jose E. Gonzalez
1Research sites
30Patients around the world

This study is for people with

Leukemia
Acute lymphoblastic leukemia

Requirements for the patient

To 60 Years
All Gender

Medical requirements

Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia.
MRD detectable in complete response above the limit of quantification according to FCM.
Performance status 0-2 on the ECOG scale.
No prior organ damage.
Having a potential related or unrelated donor.
Performance status on the ECOG scale greater than 2.
HCT-CI greater than 3 points.
Patients who do not wish to participate in clinical study.
Active central nervous system infiltration CNS3.
Active extramedullary disease.
Having previously received blinatumomab.
Absence of related or unrelated donors.

Sites

Hospital Universitario Dr. José Eleuterio González
Recruiting
Av. Dr. José Eleuterio González, Mitras Centro, 64460 Monterrey, N.L., Mexico
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