Comparison of Denervation Techniques for the Treatment of Knee Osteoarthritis: Continuous Ablative Radiofrequency Vs. Chemical Denervation with Absolute Alcohol
288 patients around the world
Available in Brazil
This randomized clinical trial compares continuous ablative radiofrequency and chemical
denervation with absolute alcohol for pain relief in patients with knee osteoarthritis
refractory to conventional treatments. Participants will be randomly assigned to one of
the two procedures, with outcomes assessed based on pain reduction, functional
improvement, quality of life, and safety. Follow-ups will be conducted for up to six
months to evaluate the durability of pain relief, providing evidence to guide clinical
management of chronic knee osteoarthritis pain.
Federal University of São Paulo
1Research sites
288Patients around the world
This study is for people with
Osteoarthritis
Requirements for the patient
From 18 Years
All Gender
Medical requirements
Adults aged ≥ 18 years.
Knee pain for more than 3 months.
Clinical and imaging-confirmed diagnosis of knee osteoarthritis, based on X-ray, ultrasound, or magnetic resonance imaging (MRI).
History of major joint interventions, such as previous knee surgery or arthroplasty.
Severe joint effusion.
Coagulation disorders or other clinical contraindications for the procedure.
Uncontrolled comorbidities that increase procedural risk.
Body mass index (BMI) > 35.
Cognitive impairment that affects the ability to understand and respond to pain assessment instruments.
Sites
Universidad Federal de São Paulo - Unifesp
R. Sena Madureira, 1500 - Vila Clementino, São Paulo - SP, 04021-001