Last updated 45 days ago

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines

600 patients around the world

Available in Brazil, Argentina

Takeda

13Research sites

600Patients around the world

This study is for people with

Arthritis

Psoriasic arthritis

From 18 Years

All Gender

: The participant is aged 18 years or older at the time of signing the informed consent form (ICF).
The participant has had signs and symptoms consistent with PsA for at least 3 months.
The participant meets the Classification Criteria for Psoriatic Arthritis (CASPAR criteria).
The participant has active arthritis as shown by a minimum of >=3 tender joints in TJC68 and >=3 swollen joints in SJC66 at the screening and baseline (Day 1) visits.
The participant has at least 1 active lesion of plaque PsO >=2 cm in diameter, or any nail or nail bed changes characteristic of PsO.
The participant has had at least one of the following:
Inadequate response to a nonsteroidal anti-inflammatory drug (NSAID).
Inadequate response to a conventional synthetic disease-modifying antirheumatic drug (csDMARD).
Biological disease-modifying antirheumatic drug (DMARD)-inadequate response (Bio-IR): Inadequate response to up to 2 biologic DMARDs.

: The participant has other disease(s) that might confound the evaluations of benefit of zasocitinib therapy, including but not limited to rheumatoid arthritis, axial spondyloarthritis, systemic lupus erythematosus, Lyme disease, gout, or fibromyalgia.
The participant has a concomitant comorbid skin condition that, in the opinion of the investigator, would interfere with the study assessments, such as evidence of non-plaque PsO (erythrodermic, pustular, predominately guttate PsO, inverse, or drug-induced PsO).

Centro Polivalente de Asistencia e Investigación Clínica - CER San Juan

Laprida 532 Este, San Juan

Instituto de Investigaciones Clínicas Quilmes

Sarmiento 315, Quilmes, Buenos Aires, Argentina

Consultora Integral de Salud SRL - Centro Médico Privado

Viamonte 544, Barrio General Paz - Córdoba

Hospital Italiano de La Plata

Av. 51 entre 29 y 30 Nro 1725, La Plata, Buenos Aires

Centro de Investigaciones Reumatológicas

Las Piedras 108, San Miguel de Tucumán

Centro Integral de Medicina Respiratoria (CIMER) - Tucumán

Combate de San Lorenzo 1241, T4000CBC San Miguel de Tucumán, Tucumán, Argentina

Hospital General de Agudos J. M. Ramos Mejía - Buenos Aires, CABA

Urquiza 609, CABA, Buenos Aires

Aprillus Asistencia e Investigación

Terrada 89, Flores, CABA

Centro Paulista de Investigação Clínica - CEPIC

R. Moreira e Costa, 342 - Ipiranga, São Paulo - SP, 04266-010

Centro Mineiro de Pesquisa - CMIP

Rua Delfim Moreira, 186, Centro Juiz de Fora, Minas Gerais, CEP: 36010-570

SponsorTakeda

Study typeInterventional

Conditions

Psoriasic arthritis

Requirements

From 18 YearsAll Gender

Unique study IDclinicaltrials.gov

NCT06671496