Last updated 25 days ago

A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

406 patients around the world

Available in Argentina, Puerto Rico, Brazil

Karuna Therapeutics

11Research sites

406Patients around the world

This study is for people with

Alzheimer disease

Requirements for the patient

To 90 Years

All Gender

Medical requirements

: Patients who are 55 to 90 years of age, inclusive, at the time of Screening (Visit 1).
Patients who are diagnosed with possible AD or probable AD.
Patient must have a magnetic resonance imaging (MRI) or computed tomography (CT) scan of the brain taken during or subsequent to the onset of dementia to rule out other central nervous system (CNS) disease that could account for the dementia syndrome.
Patient must have a history of psychotic symptoms for at least 2 months prior to Screening (Visit 1).
Other protocol-defined criteria apply.

: Psychotic symptoms that are primarily attributable to a condition other than the AD causing the dementia.
History of major depressive episode with psychotic features during the 12 months prior to Screening, or history of bipolar disorder, schizophrenia, or schizoaffective disorder.
Patients are not able to participate if they have certain safety concerns, including certain laboratory test irregularities.
Other protocol-defined criteria apply.

Sites

L2IP Instituto de Pesquisas Clínicas - Brasilia

Recruiting

SGAS 613, Conj. E Bloco A , Sala 06 - Subsolo , Asa Sul - Brasília/DF, CEP: 70.200-730

CPQuali Pesquisa Clínica

Recruiting

Avenida Angélica, 916 Conjunto 506 - São Paulo 01228-000

Clinilive - Maringá

Recruiting

R. Arthur Thomas, 806 - Centro, Maringá - PR, 87013-250, Brazil

Ruschel Medicina e Pesquisa Clínica

Recruiting

Rua Guilhermina Guinle 151 - Estado de Río de Janeiro 22270-060

IPq-HCFMUSP - Instituto de Psiquiatria do Hospital das Clínicas da FMUSP

Recruiting

R. Dr. Ovídio Pires de Campos, 785 - Cerqueira César, São Paulo - SP, 05403-010, Brazil

BR Trials - Pesquisa Clínica - Sao Paulo

Recruiting

Praça Tomás Morus,81 - 9º andar - Perdizes

Hospital Alemão Oswaldo Cruz (HAOC)

Recruiting

R. Treze de Maio, 1815 - Bela Vista, São Paulo - SP, 01323-020, Brazil

Santa Cruz Behavioral PSC - Puerto Rico

Recruiting

73 Cll Santa Cruz, Bayamón, 00961, Puerto Rico

CDT Grupo Médico San Pablo Inc. - Puerto Rico

Recruiting

Cll Santa Cruz, Bayamón, 00961, Puerto Rico

Instituto De Neurología Dra. Ivonne Fraga - Puerto Rico

Recruiting

708 Av. Juan Ponce de León #102, San Juan, 00918, Puerto Rico

StudyADEPT-4

SponsorKaruna Therapeutics

Study typeInterventional

Conditions

Alzheimer disease

Requirements

To 90 YearsAll Gender

Unique study IDclinicaltrials.gov

NCT06585787