Last updated 4 years ago

Thymol on Netrin-1 on Obese Patients

30 patients around the world

Available in Mexico

Objective: To evaluate the effect of thymol administration on the serum concentration of netrin-1 in obese subjects. Material and methods: this is a randomized, double-blind, placebo-controlled clinical trial design. Inclusion criteria: 1. - Subjects between 18 and 35 years old. 2. - Subjects with BMI ≥ 30.0 and ≤35.0. 3. - Subjects with systolic blood pressure less than 135 mmHg. 4. - Subjects with diastolic blood pressure less than 85 mmHg. 5. - Voluntary acceptance and signing of the informed consent. These patients will be randomly assigned to two groups, one will have the intervention with thymol 200 mg every 8 hours for 90 days while the other will have placebo with Mg 200 mg every 8 hours for 90 days. Statistical analysis: quantitative variables: means and standard deviation. Qualitative variables: frequencies and percentages. In the comparison according to the serum level of netrin-1 between the two groups after the intervention: t student for quantitative variables, Chi square for qualitative variables. Statistical significance p equal to or less than 0.05.

Centro Universitario de Ciencias de la Salud, Mexico

30Patients around the world

Requirements for the patient

To 35 Years

All Gender

Medical requirements

: Subjects between 18 and 35 years old.
BMI ≥ 30.0 and ≤35.0
Systolic blood pressure less than 135 mmHg.
Diastolic blood pressure less than 85 mmHg.

: Subjects who are known to have a diagnosis, receive treatment, or are observed with:
- Rheumatological and / or thyroid disease.
- Chronic kidney disease and / or CKD-EPI glomerular filtration rate less than 60 ml / min / 1.72m2.
- Innate alterations of metabolism.
- Elevation of transaminases 2 times higher than normal.
- Total cholesterol greater than 250 mg / dl.
- Triglycerides greater than 300 mg / dl.
Subjects presenting with acute illness, hospitalization, or drug treatment presented in the last 12 weeks prior to the study selection visit.
Subjects with symptoms consistent with the definition of a probable case of COVID-19, as well as any subject with a diagnosis of COVID-19.
Subjects who have had blood transfusions in the last 3 months.
Regular smokers.
Pregnant or lactating women.
Women with a desire for pregnancy or who do not have a double barrier or progestin-only contraceptive method.

SponsorCentro Universitario de Ciencias de la Salud, Mexico

Study typeInterventional

Requirements

To 35 YearsAll Gender

Unique study IDclinicaltrials.gov

NCT05427721