Last updated 3 years ago

Zotarolimus vs Sirolimus Eluting Stent in High Bleeding Risk

280 patients around the world
Available in Mexico
Instituto Nacional de Cardiologia Ignacio Chavez
280Patients around the world

Requirements for the patient

From 18 Years
All Gender

Medical requirements

Patients 18 years old or older with an ischemic de-novo lesion(s) in coronary artery or coronary bypass graft suitable for percutaneous coronary intervention, in context of acute coronary syndrome or chronic coronary syndrome with evidence of ischemia by non-invasive study or pressure guidewire that can be treated by DES, and has at least 1 major or 2 minor Academic Research Consortium High Bleeding Risk criteria:
Major criteria:
1. Anticipated use of long-term oral anticoagulation
2. Severe or end-stage Chronic Kidney Disease (CKD) (eGFR <30 mL/min)
3. Hemoglobin < 11 g/dL
4. Spontaneous bleeding requiring hospitalization or transfusion in the last 6 months, or any time, if recurrent.
5. Moderate or severe baseline thrombocytopenia (<100,000/uL)
6. Chronic bleeding diathesis
7. Liver cirrhosis with portal hypertension
8. Active malignancy (excluding nonmelanoma skin cancer) within the past 12 months
9. Previous spontaneous intracranial hemorrhage
10. Previous traumatic intracranial hemorrhage within the past 12 months
11. Presence of Brain Arteriovenous malformation (AVM)
12. Moderate or severe ischemic stroke (NIHSS score equal or more than 5) within the past 6 months
13. Non-deferrable major surgery on DAPT
14. Recent major surgery or major trauma within 30 days before PCI
Minor Criteria:
1. Age 75 years old and older
2. Moderate CKD (eGFR 30-59 mL/min)
3. Hemoglobin 11 - 12.9 g/dL in men and 11 - 11.9 g/dL in women
4. Spontaneous bleeding requiring hospitalization or transfusion within the past 12 months, not meeting major criterion
5. Long term use of NSAIDs or steroids
6. Any ischemic stroke at any time not meeting major criterion
STEMI undergoing primary PCI
Cardiogenic shock or resuscitation with uncertain neurological status at arrival to PCI
Unprotected left main lesion
Reference diameter larger or shorter than available stents
Life expectancy < 12 months
In-stent restenosis o thrombosis of previous stent
Inability to give written consent
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