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Stereotactic Body Radiation Therapy (SBRT) for Unresectable Liver Metastases
43 patients around the world
Available in
Brazil
University of Sao Paulo
1
Research sites
43
Patients around the world
Requirements for the patient
From 18 Years
All Gender
Medical requirements
Inclusion criteria
Karnofsky Performance Scale (KPS) equal or greater than 70
1 to 4 liver metastases with an individual maximum diameter of up to 5 cm
Lesions considered unresectable or patients considered unfit for surgery
Histology of the primary tumor: colorectal adenocarcinoma, carcinoma of the anal canal or gastrointestinal neuroendocrine tumors.
Absence of evidence of extra-hepatic disease or extra-hepatic disease to be treated with curative intent.
Minimum interval of 2 weeks between systemic chemotherapy and SBRT.
Adequate bone marrow function defined as:
absolute neutrophils count > 1,800 cells / mm 3
platelets > 100,000 cells / mm 3
hemoglobin > 8.0 g / dl ( transfusion or other intervention accepted)
Exclusion criteria
Concomitant chemotherapy
Prior radiotherapy to the upper abdomen
Pregnancy
Underlying Cirrhosis
Active hepatitis or clinically significant liver failure
Prior invasive neoplasm except for non-melanoma skin cancer, or unless more than five years without evidence of disease
Severe Comorbidity
Current anticoagulant treatment
Sites
Fundação Faculdade de Medicina - Instituto do Cancer do Estado de São Paulo
Recruiting
Consult
View site
Av. Dr. Arnaldo, 455 - Cerqueira César, Pacaembu - SP, 01246-903
View site
Consult
See details
Contact us
Contact us
Sponsor
University of Sao Paulo
Study type
Interventional
Requirements
From 18 Years
All Gender
Unique study ID
clinicaltrials.gov
NCT02185443
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