Last updated 4 days ago

Stereotactic Body Radiation Therapy (SBRT) for Unresectable Liver Metastases

43 patients around the world
Available in Brazil
University of Sao Paulo
1Research sites
43Patients around the world

Requirements for the patient

From 18 Years
All Gender

Medical requirements

Karnofsky Performance Scale (KPS) equal or greater than 70
1 to 4 liver metastases with an individual maximum diameter of up to 5 cm
Lesions considered unresectable or patients considered unfit for surgery
Histology of the primary tumor: colorectal adenocarcinoma, carcinoma of the anal canal or gastrointestinal neuroendocrine tumors.
Absence of evidence of extra-hepatic disease or extra-hepatic disease to be treated with curative intent.
Minimum interval of 2 weeks between systemic chemotherapy and SBRT.
Adequate bone marrow function defined as:
absolute neutrophils count > 1,800 cells / mm 3
platelets > 100,000 cells / mm 3
hemoglobin > 8.0 g / dl ( transfusion or other intervention accepted)
Concomitant chemotherapy
Prior radiotherapy to the upper abdomen
Pregnancy
Underlying Cirrhosis
Active hepatitis or clinically significant liver failure
Prior invasive neoplasm except for non-melanoma skin cancer, or unless more than five years without evidence of disease
Severe Comorbidity
Current anticoagulant treatment

Sites

Fundação Faculdade de Medicina - Instituto do Cancer do Estado de São Paulo
Recruiting
Av. Dr. Arnaldo, 455 - Cerqueira César, Pacaembu - SP, 01246-903
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