Effect of Supplementation With ω-3 Fatty Acids, Vitamin D and Calcium in Patients With Acute Lymphoblastic Leukemia.
40 patients around the world
Available in Mexico
In pediatric hematological patients, the administration of high and prolonged doses of
corticosteroids has a negative effect on bone metabolism, causing a significant reduction in
bone mineral density (BMD). Maintaining adequate levels of vitamin D (VD) and calcium is
crucial for bone health, and deficiencies in these nutrients increase the risk of
osteoporosis. Children with acute lymphoblastic leukemia (ALL) have been found to have a high
prevalence of VD deficiency. Bone turnover markers (BTMs) are substances produced by
osteoblasts and osteoclasts that provide information about the dynamic remodeling of bone.
Limited research has investigated the role of BTMs in pediatric ALL patients receiving VD
supplementation.
Emerging evidence suggests that long-chain ω-3 polyunsaturated fatty acids (LCPUFA-ω3) play a
significant role in bone health. Consumption of eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA) may inhibit bone resorption and promote bone formation in humans.
Currently, there are no randomized controlled clinical trials comparing the effects of
combined supplementation with LCPUFA-ω3, VD, and calcium on BTMs in children with cancer.
Coordinación de Investigación en Salud, Mexico
40Patients around the world
This study is for people with
Leukemia
Acute lymphoblastic leukemia
Requirements for the patient
To 17 Years
All Gender
Medical requirements
SponsorCoordinación de Investigación en Salud, Mexico