Last updated 14 days ago

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

750 patients around the world
Available in Brazil, Argentina, Chile, Colombia, Mexico
Amgen
35Research sites
750Patients around the world

This study is for people with

Lung cancer
Non-small cell lung carcinoma

Requirements for the patient

To 100 Years
All Gender

Medical requirements

Histologically or cytologically confirmed diagnosis of nonsquamous stage IV or advanced Stage IIIB or IIIC NSCLC with KRAS p. G12C mutation and negative for PD-L1 expression by central testing or local laboratory testing confirmed through central testing
No history of systemic anticancer therapy in metastatic/non-curable settings
Eastern Cooperative Oncology Group (ECOG) ≤ 1
Mixed histology NSCLC with either small-cell or large-cell neuroendocrine cell component or predominant squamous cell histology
Participants with tumors known to harbor molecular alterations for which targeted therapy is locally approved
Symptomatic (treated or untreated) brain metastases
Gastrointestinal (GI) tract disease causing the inability to take oral medication
Myocardial infarction within 6 months of randomization, unstable arrhythmias, or unstable angina
Prior therapy with a KRAS G12C inhibitor

Sites

Hospital Británico de Buenos Aires - CABA
Hospital Británico de Buenos Aires - CABA
Recruiting
Perdriel 74, CABA, Buenos Aires
Centro de Investigaciones Clínicas - Clínica Viedma - Río Negro
Centro de Investigaciones Clínicas - Clínica Viedma - Río Negro
Recruiting
25 de mayo 174, Viedma, Río Negro
Fundación Cori para la Investigación y Prevención del Cáncer - La Rioja
Recruiting
Dorrego 269, La Rioja
Fundación Ars Médica - San Salvador de Jujuy
Recruiting
Independencia 1167, San Salvador de Jujuy, Jujuy
Centro Oncológico Korben
Recruiting
Cdad. de La Paz 353, C1426 CABA, Argentina
Sanatorio Parque - Rosario
Recruiting
Boulevard Oroño 860, Rosario, Santa Fe
Instituto Médico Especializado Alexander Fleming - CABA, Buenos Aires
Recruiting
Av. Crámer 1180, CABA, Buenos Aires
Hospital Italiano de La Plata
Recruiting
Av. 51 entre 29 y 30 Nro 1725, La Plata, Buenos Aires
Centro de Diagnóstico Investigación y Tratamiento - CEDIT - Salta
Recruiting
Santiago del Estero 1415, Salta Capital
Instituto Argentino de Diagnóstico y Tratamiento - IADT
Recruiting
Marcelo Torcuato de Alvear 2346, C1122 CABA
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