Last updated 7 days ago

An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)

5500 patients around the world
Available in Colombia, United States, Mexico, Chile, Peru, Argentina, Brazil
This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard adjuvant endocrine therapy for patients with ER+/HER2- early breast cancer with intermediate-high or high risk for disease recurrence who completed definitive locoregional therapy (with or without chemotherapy). The planned duration of treatment in either arm of the study is 7 years. Eligible patients must have intermediate-high or high risk of recurrence as defined by specified clinical and biologic criteria. Concurrent use of abemaciclib is permitted in both arms. The primary endpoint of the study is Invasive breast cancer-free survival (IBCFS) and main secondary endpoints include Invasive disease-free survival (IDFS), Distant relapse-free survival (DRFS), Overall survival (OS), Safety and Clinical Outcome Assessments (COAs). Patients will be followed for 10 years from randomization of the last patient.
AstraZeneca
7Research sites
5500Patients around the world

This study is for people with

Breast Cancer

Requirements for the patient

To 130 Years
All Gender

Medical requirements

Sites

Hospital Británico de Buenos Aires - CABA
Hospital Británico de Buenos Aires - CABA
Recruiting
Perdriel 74, CABA, Buenos Aires
Centro de Investigaciones Clínicas - Clínica Viedma - Río Negro
Centro de Investigaciones Clínicas - Clínica Viedma - Río Negro
Recruiting
25 de mayo 174, Viedma, Río Negro
CIPREC Centro de Investigación y Prevención Cardiovascular - CABA
CIPREC Centro de Investigación y Prevención Cardiovascular - CABA
Recruiting
Av. Pueyrredon 1746, CABA, Buenos Aires
Hospital Alemán
Recruiting
Av. Pueyrredón 1640, CABA, Buenos Aires
Fundación CENIT para la Investigación en Neurociencias
Recruiting
Juncal 2222, C1125 CABA, Argentina
Centro Médico San Roque S.R.L. - Tucumán
Recruiting
Balcarce 579, Tucumán
Clínica El Castaño
Recruiting
Av Libertador San Martin 952, San Juan
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