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A Study of Ustekinumab or Guselkumab in Pediatric Participants With Active Juvenile Psoriatic Arthritis

60 patients around the world
Available in Argentina
Janssen Research & Development, LLC
5Research sites
60Patients around the world

This study is for people with

Arthritis
Psoriasic arthritis

Requirements for the patient

To 17 Years
All Gender

Medical requirements

Diagnosis of juvenile psoriatic arthritis (jPsA) by Vancouver criteria with exclusion of enthesitis-related arthritis (ERA). Diagnosis made >=3 months (that is, 90 days) prior to screening
Active disease in at least greater than or equal to (>=) 3 joints at screening and at week 0 (defined as swelling or loss of motion with pain and/or tenderness. Swelling alone meets the criteria for an active arthritic joint. In the absence of swelling, loss of motion with pain or tenderness or both pain and tenderness meet the criteria for an active arthritic joint
Have active disease despite previous non-biologic disease modifying anti-rheumatic drug (DMARD) and/or non-steroidal anti-inflammatory drug (NSAID) therapy: Non-biologic DMARD therapy is defined as taking a non-biologic DMARD for at least 12 weeks or evidence of intolerance; NSAID therapy is defined as taking an NSAID for at least 4 weeks or evidence of intolerance
Concurrent use of methotrexate, sulfasalazine, leflunomide, oral corticosteroids or NSAIDs is permitted but must be on stable dose
Participants must be up to date with all immunizations in agreement with current local immunization guidelines for immunosuppressed patients
Prior use of anti-TNFα agents, IL-17 inhibitors and other biologics (except non-responders to IL-23 inhibitors) and JAK inhibitors are permitted with sufficient washout period
Participants with enthesitis-related arthritis (ERA)
Have a history of latent or active granulomatous infection, including tuberculosis (TB), histoplasmosis, or coccidioidomycosis prior to screening
Have a history of, or ongoing, chronic or recurrent infectious disease
Has evidence of herpes zoster infection within 8 weeks prior to Week 0
Have a known history of hepatitis C infection or test positive at screening

Sites

STAT Research - CABA
STAT Research - CABA
Recruiting
Av. Callao 875, CABA, Buenos Aires
Centro Médico Privado de Reumatología - San Miguel de Tucumán
Recruiting
Lavalle 506, San Miguel de Tucumán
Hospital de Niños de la Santísima Trinidad - Córdoba
Recruiting
Ferroviarios 1250, Córdoba
Instituto Médico Platense SA - La Plata
Recruiting
Boulevard 51 Nro 315, La Plata, Buenos Aires
Instituto CAICI - Rosario, Santa Fe
Recruiting
Mendoza 2612, Rosario, Santa Fe
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