Clinical and Microbiological Evaluation of Laser Therapy in the Treatment of Periodontal Disease in Stages III and IV
20 patients around the world
Available in Brazil
Periodontitis is a chronic, inflammatory and multifactorial disease, caused by an
interaction between debiotic biofilm and its products and an exacerbated host response,
leading to the progressive destruction of the supporting periodontium (bone, cement and
periodontal ligament), causing loss of clinical attachment. and radiographic, bleeding on
probing and periodontal pocket formation. Periodontal disease has a high prevalence and
is one of the main causes of edentulism, with a great negative impact on chewing
function, aesthetics and quality of life related to oral health. It is, therefore,
considered a serious public health problem.
Conventional periodontal therapy consists of scaling and root planing (SRP) and control
of supragingival plaque, but in some cases it has been shown to be ineffective in
treating periodontitis, especially in difficult to access areas such as furcations and
deep pockets. These cases benefit from adjuvant therapies, such as laser therapy, to help
heal periodontal tissues, reduce microorganisms and improve clinical parameters.
Photobiomodulation and photodynamic therapy have been widely applied in the treatment of
periodontal disease, due to their clinical, cellular and bactericidal effects. When
associated with conventional periodontal therapy, its benefits increase, promoting a
significant reduction in probing depth, number of deep pockets and bleeding. Furthermore,
significant reduction of periodontopathogens and Candida albicans can be observed in the
literature after photobiomodulation and photodynamic therapy.
Despite the benefits found when different laser therapy protocols are used in periodontal
treatment, due to the lack of studies with high methodological quality and weak evidence
in the existing literature, more studies are needed to prove their effects, establish
appropriate protocols and evaluate the antimicrobial potential in periodontopathogens,
which remains debatable, as recent systematic reviews point out.
The direct benefits of this study are the treatment of periodontal disease for the
participants and for the scientific community to indicate new forms of periodontal
therapy using different protocols of laser therapy associated with periodontal
instrumentation. All tooth pocket sites in all groups will receive treatment.
Universidade Federal Fluminense
1Research sites
20Patients around the world
This study is for people with
Dental and oral disorders
Periodontitis
Requirements for the patient
To 70 Years
All Gender
Medical requirements
Adult participants with periodontal disease.
Four or more periodontal sites with PPD≥6 mm and CAL≥5 mm, non-adjacent.
Generalized periodontitis, with more than 30% of the sites involved (Caton et al., 2018).
Stages III and IV of periodontal disease (Caton et al., 2018).
Participants with hypersensitivity to the components of the 0.005% methylene blue gel.
Received periodontal treatment in the last six months.
Drugs (alcoholics, use of anti-inflammatories and antibiotics in the last 3 months).
Any evidence of systemic modifying factors which may directly interfere with the completion of the work (bias), such as:
Pregnant and breastfeeding women.
Hormone replacement therapy.
Smoking.
Hyperglycemia.
Osteoporosis.
Diagnosed with HIV+ or AIDS.
Sites
Universidade Federal Fluminense
Recruiting
R. Miguel de Frias, 9 - Icaraí, Niterói - RJ, 24220-900, Brazil